“Ancient” (Sclerosing) Thymomas

Thymomas: a continuing challenge.

Thymic epithelial tumors usually are broadly classified into two main categories: thymoma and thymic carcinoma. In adults, thymomas are the most common primary tumor in the anterior mediastinum.[2] A large variety of paraneoplastic or parathymic syndromes may suggest the presence of a thymoma.[3] Myasthenia gravis coexists in approximately 30% to 40% of patients with thymoma.[4] It is still unc...

Thymomas: clinical-pathological correlations.

AIM Since World Health Organization (WHO) histologic typing of tumors of the thymus publication in 1999 only a few studies correlated this classification with the clinical features of the patients. We present the results of a retrospective analysis on patients, operated on for a thymoma, whose specimens were available, to compare the WHO thymoma histologic classification to the clinical behavio...

Proteomic Signatures of Thymomas

Based on the histological features and outcome, the current WHO classification separates thymomas into A, AB, B1, B2 and B3 subtypes. It is hypothesized that the type A thymomas are derived from the thymic medulla while the type B thymomas are derived from the cortex. Due to occasional histological overlap between the tumor subtypes creating difficulties in their separation, the aim of this stu...

Benign sclerosing pneumocytoma of lung (sclerosing haemangioma).

Cells immunoreactive for neuropeptide in human thymomas.

The presence of opioid peptides, bombesin, and substance P was investigated by immunohistochemistry in tissue sections from six human thymomas. The number of immunoreactive cells seemed to vary from one case to another. Ultrastructural investigation, showing the presence of desmosomes in labelled cells, allowed these cells to be classified as epithelial lineage cells. The occurrence of cells co...